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4th International Conference on Innovative Computing (ICIC) ; : 19-24, 2021.
Article in English | Web of Science | ID: covidwho-1985462

ABSTRACT

Object detection and tracking are one of the key features of a robust autonomous mobile robot, allowing it to navigate places and avoid obstacles. The Mobile robotics market and proliferation has been growing and the Covid-19 era has added another boost to this area where more and more interest is being drawn to the autonomous capabilities of these machines. In this paper we propose a hardware based model to detect and track objects based on color. We propose robust object detection and tracking with minimum environmental constraints to improve accuracy using our algorithm, and capable of behaving well in unknown environmental conditions. At the end of the analysis, the robot was able to detect the object and track it well. We also show frequency analysis, compression and error analysis of the underlying technique. Experimental outcomes verify improved accuracy of our algorithm.

2.
Biomed Signal Process Control ; 68: 102605, 2021 Jul.
Article in English | MEDLINE | ID: covidwho-1163454

ABSTRACT

The novel Corona Virus (COVID-19) has become the reason for the world to declare it as a global pandemic, which has already taken many lives from all around the world. This pandemic has become a disaster since the spreading rate from person to person is incredibly high and many techniques have come forth to aid in stopping the infection. Although various types of methods have been put into implementation, the search and suggestions of new approaches to reduce the increasing rate of infection will never come to an end until a vaccine terminates this pandemic. This study focuses on proposing a new framework that is based on Deep Learning algorithms for recognizing the COVID-19 cases, mostly in public places. The algorithms include Background Subtraction for extracting the foreground of thermal images from thermal videos generated by Thermal Cameras through the Thermal Imaging process and the Convolutional Neural Network for detecting people infected with the virus. This automated prototype works in a real-time scenario that helps identify people with the disease and will try to trace it while separating them from having any other contact. This proposal intends to achieve a satisfying growth in determining the real cases of COVID-19 and minimize the spreading rate of this virus to the max, ultimately avoiding more deaths.

3.
Acta Pharm Sin B ; 11(1): 222-236, 2021 Jan.
Article in English | MEDLINE | ID: covidwho-871726

ABSTRACT

Lianhuaqingwen (LHQW) capsule, a herb medicine product, has been clinically proved to be effective in coronavirus disease 2019 (COVID-19) pneumonia treatment. However, human exposure to LHQW components and their pharmacological effects remain largely unknown. Hence, this study aimed to determine human exposure to LHQW components and their anti-COVID-19 pharmacological activities. Analysis of LHQW component profiles in human plasma and urine after repeated therapeutic dosing was conducted using a combination of HRMS and an untargeted data-mining approach, leading to detection of 132 LHQW prototype and metabolite components, which were absorbed via the gastrointestinal tract and formed via biotransformation in human, respectively. Together with data from screening by comprehensive 2D angiotensin-converting enzyme 2 (ACE2) biochromatography, 8 components in LHQW that were exposed to human and had potential ACE2 targeting ability were identified for further pharmacodynamic evaluation. Results show that rhein, forsythoside A, forsythoside I, neochlorogenic acid and its isomers exhibited high inhibitory effect on ACE2. For the first time, this study provides chemical and biochemical evidence for exploring molecular mechanisms of therapeutic effects of LHQW capsule for the treatment of COVID-19 patients based on the components exposed to human. It also demonstrates the utility of the human exposure-based approach to identify pharmaceutically active components in Chinese herb medicines.

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